Alongside countless collaborations, Wheeler is constantly evolving her solo performances, which blend improvised and looped vocals with numerous instruments – including mbira, autoharp, and theremin – processing them with effects to blur the line between the organic and the synthetic.

In the studio, Wheeler has worked with a variety of acts, ranging from turntablist pioneer DJ Logic to house producer Fred P in his side project Black Jazz Consortium. In a live setting, she has teamed up with ambient artists, including Laraaji and Murcof, as well as jazz musicians like Matana Roberts and Nicole Mitchell. In 2019, Wheeler took part in the Art Ensemble of Chicago's 50th anniversary celebration, »We Are on the Edge,« and in 2020, she performed a commissioned piece for the Bang on a Can Marathon.