In their quest to explore nonhuman forms of communication, they have developed a collection of experimental research and education tools named Ontological Machines. Their work is also deeply shaped by the Latin American context, where precarity enables creative action, and ancient technologies meet cutting-edge forms of production. Their current lines of research are shifting towards exploring the hard problem of consciousness and the close relationship between mind and matter, where magic appears to be fundamental. Sound remains their interface to the universe.

The collective is founded by Paloma López, who comes from a Communication Sciences background where she saw the anthropocentric focus on the analysis of communication as a social phenomenon; Leslie Garcia who studies integral design, a strange hybrid between industrial and graphic design; and Thiago Hersan who worked on improving semiconductor manufacturing technologies before becoming more interested in exploring non-traditional uses of technology and their cultural effect. Lopez and Garcia remain active members.

Interspecifics have been supported by and shown work at a wide range of organisations including FACT Liverpool, DAAD, Bauhaus-Universität Weimar, and Universität der Künste Berlin, European Congress for Artificial Intelligence in York, Spektrum, Centro Cultural de España, and CTM Festival. In Mexico and South America they have been supported by the Laboratorio Arte Alameda, Telefonica Foundation, Bancomer BBVA Foundation, The National Fund for Culture and the Arts in México, the Museum of Modern art in Medellin in Colombia, the National Council for Culture and the Arts and Museum of Contemporary art in Chile, INDEX at the University Museum of Contemporary Art, and Tamayo Museum.