One of her early artistic efforts was Digital TV Dinner, a pioneering example of glitch art.

Fenton was lead software engineer on the Bally Astrocade home game system and helped add features to make this platform useful for visual & audio artists. Along with Marc Canter and Mark Pierce, she founded the multimedia tools company MacroMind and wrote their first music and animation programs for the Apple Macintosh. MacroMind later moved to San Francisco and changed its name to MacroMedia.

Jamie then did educational research and distributed computing research, continuing to develop audio and video software. Now semi-retired, Jamie added some code to Olivia Jack's Hydra project, creating a tool that can randomly mutate Hydra sketches.