Lewis founded Obx Laboratory for Experimental Media, where he conducts research/creation projects exploring computation as a creative and cultural material. He directs the Initiative for Indigenous Futures, and co-directs the Indigenous Futures Research Centre, the Indigenous Protocol and AI Workshops, the Aboriginal Territories in Cyberspace research network, and the Skins Workshops on Aboriginal Storytelling and Video Game Design.

Lewis is deeply committed to developing intriguing new forms of expression by working on conceptual, critical, creative, and technical levels simultaneously. His creative and production work has been featured at Ars Electronica, Mobilefest, Elektra, Urban Screens, ISEA, SIGGRAPH, and FILE, among other, and has been recognized with the inaugural Robert Coover Award for Best Work of Electronic Literature, two Prix Ars Electronica Honorable Mentions, several imagineNATIVE Best New Media award and six solo exhibitions. In addition to being lead author on the award-winning »Making Kin with the Machines« essay and editor of the groundbreaking »Indigenous Protocol and Artificial Intelligence« Position Paper, Lewis has contributed to chapters in collected editions covering mobile media, video game design, machinima, and experimental pedagogy with Indigenous communities, as well as numerous journal articles and conference papers.

Currently Lewis is the University Research Chair in Computational Media and the Indigenous Future Imaginary as well as Professor of Computation Arts at Concordia University, Montréal. Born and raised in northern California, Lewis is Hawaiian and Samoan.