After studying piano and violin, Fuchs forged her own path in the turbulent, transformative countercultural scene of 1960s Munich. By the decade's end, she founded Anima-Sound, a banner for her research that would continue for 20 years in tandem with her partner, sculptor Paul Fuchs. Her performance practice is largely situational and improvisational, determined by the acoustics of the space in which she performs as well as the input of any collaborators involved. In addition to vocals and traditional instruments, Fuchs makes use of materials such as wood, granite, and bronze, elevating their individual resonances to a distinct focal point.

In 2020, Play Loud! Productions released Im Lungau, a recording of Anima's set at the Tage Freier Musik festival in 1977. Limpe Fuchs continues activity in various configurations, including the Occhio Quartet and Bunte Truppe as well as duo projects with Jacques Foschia, Ignaz Schick, and Evan Parker.